Molecular features and clinical outcomes in surgically treated low-grade diffuse gliomas in patients over the age of 60.

Ramin A MorshedSeunggu J HanShawn L Hervey-JumperMelike PekmezciIrene TronconSusan M ChangNicholas A ButowskiMitchel S Berger

Published in: Journal of neuro-oncology (2018)

Older patients with diffuse gliomas may safely undergo aggressive treatment with surgical resection and adjuvant therapy. Elderly patients with low grade gliomas have worse clinical outcomes compared to their younger counterparts. This may be due to an increased frequency of diffuse astrocytoma IDH-wildtype tumors in this age group.

Keyphrases

low grade
high grade
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
middle aged
replacement therapy