Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis.

Bianca Maria ScicchitanoSilvia SorrentinoGabriella ProiettiGina LamaGabriella DobrowolnyAngela CatizoneElena BindaLuigi Maria LaroccaGigliola Sica

Published in: Cancer cell international (2018)

Although further studies are needed to determine the exact mechanism by which LEV makes GBM stem cells more sensitive to TMZ, these results suggest that the clinical therapeutic efficacy of TMZ in GBM might be enhanced by the combined treatment with LEV.

Keyphrases

stem cells
cell proliferation
oxidative stress
cell death
cell cycle
cell cycle arrest
case control
molecular dynamics
smoking cessation