Login / Signup

Sharing extended summary data from contemporary genetics studies is unlikely to threaten subject privacy.

Silviu-Alin Bacanu
Published in: PloS one (2017)
To investigate the possibility of SBCC detection in multi-ethnic cohorts, we generalize the Masca et al. approach by theoretically deriving the correlation between a subject genotype and the cohort reference allele frequencies (RAFs) for stratified cohorts. Based on the derived formula, we theoretically show that, due to background stratification noise, SBCC detection is unlikely even for mildly stratified cohorts of size greater than around a thousand subjects. Thus, for the vast majority of contemporary cohorts, the fear of compromising privacy via SBCC detection is unfounded.
Keyphrases
  • loop mediated isothermal amplification
  • health information
  • big data
  • real time pcr
  • label free
  • air pollution
  • electronic health record
  • machine learning
  • sensitive detection
  • deep learning
  • preterm birth