Study of glutathione S-transferase levels in patients receiving intravenous paracetamol perioperatively: A randomized controlled trial.

Intravenous paracetamol infusion during laparoscopic GI surgeries can lead to demonstrable, although subclinical impairment of hepatic function as evident by the rise in levels of GST and hepatic enzymes. Most of such subclinical injury did not progress to clinical hepatic impairment in otherwise healthy patients, as demonstrated by the fact that none of our patients manifested drug-induced hepatitis clinically. ᅟ ᅟ.