AKT controls protein synthesis and oxidative metabolism via combined mTORC1 and FOXO1 signalling to govern muscle physiology.
Natasha JaiswalMatthew GavinEmanuele LoroJaimarie Sostre-ColónPaul A RobersonKahealani UeharaNicole Rivera-FuentesMichael NeinastZoltan AranyScot R KimballTejvir S KhuranaPaul M TitchenellPublished in: Journal of cachexia, sarcopenia and muscle (2021)
Collectively, this study provides novel insights into the AKT-dependent mechanisms that underlie muscle protein homeostasis, function, and metabolism in both normal physiology and disuse-induced muscle wasting.