Global brain volume reductions in a sub-chronic phencyclidine animal model for schizophrenia and their relationship to recognition memory.

Nazanin DoostdarEugene KimBen GraysonMichael K HarteJoanna C NeillAnthony Christopher Vernon

Published in: Journal of psychopharmacology (Oxford, England) (2019)

A sustained sub-chronic phencyclidine-induced cognitive deficit in novel object recognition is accompanied by global brain volume reductions in female Lister Hooded rats. The relative volumes of the perirhinal cortex however are positively correlated with novel object exploration, indicating some functional relevance.

Keyphrases

working memory
resting state
functional connectivity
white matter
drug induced
bipolar disorder
cerebral ischemia
multiple sclerosis
subarachnoid hemorrhage