Cumulative dose of epinephrine and mode of death after non-shockable out-of-hospital cardiac arrest: a registry-based study.

François JavaudinWulfran BougouinLucie FanetJean-Luc DiehlDaniel JostFrankie BegantonJean-Philippe EmpanaXavier JouvenFrédéric AdnetLionel LamhautJean-Baptiste LascarrouAlain CariouFlorence Dumasnull null

Published in: Critical care (London, England) (2023)

In non-shockable OHCA with ROSC, the dose of epinephrine used during CPR is strongly associated with early cardiocirculatory death. Further clinical studies aimed at limiting the dose of epinephrine during CPR seem warranted. Moreover, strategies for the prevention and management of PRS should take this dose of epinephrine into consideration for future trials.

Keyphrases

cardiac arrest
cardiopulmonary resuscitation