Integrin αVß6 - autoantigen and driver of epithelial remodeling in colon and bile ducts in primary sclerosing cholangitis and inflammatory bowel disease.
Dominik RothMiriam M DüllLudwig J HorstAylin LindemannXenia MalzerKristina KoopSebastian ZundlerMarcel VetterAndré JefremowGisela FeltenCarol GeppertSören WeidemannMaximilian J WaldnerPeter DietrichClaudia GüntherLuis E MunozMartin HerrmannAlexander ScheffoldMarkus F NeurathJürgen SieblerChristoph SchrammAndreas E KremerMoritz LeppkesPublished in: Journal of Crohn's & colitis (2024)
Anti- αVβ6 frequently occur in patients suffering from PSC, especially in PSC-IBD. Anti- αVß6 levels positively correlate to IBD activity in PSC-IBD, but may also occur in the absence of clinically manifest IBD in PSC.