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Risk of Invasive Fungal Infections in Patients With Chronic Lymphocytic Leukemia Treated With Bruton Tyrosine Kinase Inhibitors: A Case-Control Propensity Score-Matched Analysis.

Nelson Iván Agudelo HiguitaDaniel B ChastainBrian ScottSyeda SahraLilian Vargas BarahonaJosé Henao CorderoAlfred L H LeeJose TuellsAndrés F Henao Martinez
Published in: Open forum infectious diseases (2024)
We found an adjusted elevated rate of PJP and invasive candidiasis with BTKi use. The rates are, however, low with a high number needed to harm. Additional studies stratifying other IFIs with specific BTKis are required to identify at-risk patients and preventive, cost-effective interventions.
Keyphrases
  • case control
  • chronic lymphocytic leukemia
  • end stage renal disease
  • newly diagnosed
  • chronic kidney disease
  • ejection fraction
  • prognostic factors
  • physical activity
  • patient reported outcomes