Insights on Zika virus envelope gene conservation in American outbreaks.
Mateus Vailant ThomazellaQuirino A Lima NetoFrancisco F Duarte JuniorFernando A JorgeDéborah de Castro MoreiraAmauri D Leal JuniorMayra M PresibellaIrina N RiedigerRafael A da SilvaIsabel Maria V G de CarvalhoDennis A BertoliniPublished in: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] (2020)
Phylogenetic studies with Zika virus (ZIKV) have been conducted in Brazil. In this study, we sequenced 8 new sequences of the ZIKV envelope (E) gene from strains of cases from the Paraná and Mato Grosso do Sul states in 2016. A low phylogenetic signal was observed, with more than 40% of unresolved quartets, and the Maximum Likelihood Tree grouped all sequences in the Brazilian branches within the Asian genotype. In addition, a Shannon entropy analysis was conducted, showing a high stability in the E protein through the ZIKV polyprotein. Taken together, these results suggest a high degree of conservation in the ZIKV E gene from the recent American outbreaks.