Clonidine ameliorates cisplatin-induced nephrotoxicity: impact on OCT2 and p38 MAPK pathway.

Mariam H FawzyDina M KhodeerNorhan M ElsayedYasser M AhmedNoha M Saeed

Published in: The Journal of pharmacy and pharmacology (2022)

This study suggests the promising nephroprotective impact of Clon as an OCT2 inhibitor against CP nephrotoxicity and its proficient role in attenuating oxidative stress, inflammatory status and apoptotic status.

Keyphrases

oxidative stress
optical coherence tomography
diabetic retinopathy
cell death
drug induced
mouse model
optic nerve
induced apoptosis
endoplasmic reticulum stress
heat shock