Reduction of Premature Aging Markers After Gastric Bypass Surgery in Morbidly Obese Patients.

P J HohensinnerC KaunB EbenbauerM HacklS DemyanetsD RichterM PragerJ WojtaGersina Rega-Kaun

Published in: Obesity surgery (2019)

Our data indicate a significant reduction of the proinflammatory SASP after bariatric surgery. We observed an increase in telomere length and reduced oxidative stress at telomeres. miR10a_5p which is downregulated during aging was upregulated after surgery. Overall, bariatric surgery ameliorated the premature aging phenotype.

Keyphrases

obese patients
gastric bypass
bariatric surgery
roux en y gastric bypass
weight loss
oxidative stress
minimally invasive
electronic health record
dna damage
ischemia reperfusion injury
machine learning
coronary artery disease
induced apoptosis