Exploring the impact of PDGFD in osteosarcoma metastasis through single-cell sequencing analysis.

Yujing HuangDongyan CaoManxue ZhangYue YangGengming NiuLina TangZan ShenZhichang ZhangYueqing BaiDaliu MinAina He

Published in: Cellular oncology (Dordrecht) (2024)

scRNA-seq illuminated the activation of the PDGF signaling pathway in primary lesion of non-metastatic osteosarcoma. PDGFD displayed an inhibitory effect on osteosarcoma metastasis, likely through the suppression of the EMT signaling pathway.

Keyphrases

single cell
signaling pathway
epithelial mesenchymal transition
rna seq
pi k akt
small cell lung cancer
squamous cell carcinoma
high throughput
induced apoptosis
genome wide
oxidative stress
smooth muscle