RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell function.
Hazem IbrahimDiego BalboaJonna Saarimäki-VireHossam MontaserOleg DyachokPer-Eric LundMuhmmad Omar-HmeadiJouni A KvistOm Prakash DwivediVäinö LithoviusTom BarsbyVikash ChandraSolja EurolaJarkko UstinovTiinamaija TuomiPäivi J MiettinenSebastian BargAnders TengholmTimo OtonkoskiPublished in: Diabetologia (2024)
Ultra-deep bulk RNA-seq data for pancreatic differentiation stages 3, 5 and 7 of H1 RFX6 genotypes are deposited in the Gene Expression Omnibus database with accession code GSE234289. Original western blot images are deposited at Mendeley ( https://data.mendeley.com/datasets/g75drr3mgw/2 ).
Keyphrases
- rna seq
- single cell
- gene expression
- electronic health record
- type diabetes
- big data
- cardiovascular disease
- dna methylation
- deep learning
- south africa
- emergency department
- glycemic control
- optical coherence tomography
- adipose tissue
- insulin resistance
- mass spectrometry
- data analysis
- bioinformatics analysis
- weight loss