Login / Signup

Mechanochemical C-H Arylation and Alkylation of Indoles Using 3 d Transition Metal and Zero-Valent Magnesium.

Chongyang WuJin LvHangqian FanWei-Ke SuXinjun CaiJingbo Yu
Published in: Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Although the 3 d transition-metal catalyzed C-H functionalization have been extensively employed to promote the formation of valuable carbon-carbon bonds, the persistent problems, including the use of sensitive Grignard reagents and the rigorous operations (solvent-drying, inert gas protection, metal pre-activation and RMgX addition rate control), still leave great room for further development of sustainable methodologies. Herein, we report a mechanochemical technology toward in-situ preparation of highly sensitive organomagnesium reagents, and thus building two general 3 d transition-metal catalytic platforms that enables regioselective arylation and alkylation of indoles with a wide variety of halides (including those containing post transformable functionalities and heteroaromatic rings). This mechanochemical strategy also brings unique reactivity and high step-economy in producing functionalized N-free indole products.
Keyphrases
  • transition metal
  • molecularly imprinted
  • room temperature
  • mental health
  • multidrug resistant
  • ionic liquid
  • quantum dots
  • fluorescent probe