Anti-dsDNA IgE induces IL-4 production from basophils, potentially involved in B-cell differentiation in systemic lupus erythematosus.
Sho FujimotoYojiro ArinobuKohta MiyawakiMasahiro AyanoHiroki MitomaYasutaka KimotoNobuyuki OnoKoichi AkashiTakahiko HoriuchiHiroaki NiiroPublished in: Rheumatology (Oxford, England) (2023)
These results suggest that basophils contribute to the pathogenesis of SLE by promoting B cell differentiation via dsDNA-specific IgE in patients similar to the process described in mouse models.