Cyclam-Modified Polyethyleneimine for Simultaneous TGFβ siRNA Delivery and CXCR4 Inhibition for the Treatment of CCl4-Induced Liver Fibrosis.
Aftab UllahGang ChenAbid HussainHanif KhanAzar AbbasZhanwei ZhouMuhammad ShafiqSaleem AhmadUsman AliMuhammad UsmanFaisal RazaAbrar AhmedZijie QiuMaochao ZhengDaojun LiuPublished in: International journal of nanomedicine (2021)
Our findings validate the feasibility of using PEI-Cyclam as a siRNA delivery vector for simultaneous TGFβ siRNA delivery and CXCR4 inhibition for the combined anti-fibrotic effects in a setting of CCl4-induced liver fibrosis.