Genomic Selection Signals in Andean Highlanders Reveal Adaptive Placental Metabolic Phenotypes That Are Disrupted in Preeclampsia.

Katie A O'Brien Wanjun Gu Julie A Houck Lorenz M W Holzner Hong Wa Yung Jenna L Armstrong Alice P Sowton Ruby Baxter Paula M Darwin Lilian Toledo-Jaldin Litzi Lazo-VegaAny Moreno-AramayoValquiria Miranda-GarridoJonathan A ShorttChristopher J MatarazzoHussna YasiniGraham J Burton Lorna G Moore Tatum S Simonson Andrew J Murray Colleen Glyde Julian

Published in: Hypertension (Dallas, Tex. : 1979) (2023)

Our findings reveal novel associations between putatively adaptive gene regions and phenotypes linked to oxygen delivery and placental metabolic function in highland Andeans, suggesting that such effects may be of genetic origin. Our findings also demonstrate maladaptive metabolic mechanisms in the context of preeclampsia, including dysregulation of placental oxygen consumption.

Keyphrases

genome wide
copy number
early onset
single cell
dna methylation
functional connectivity