TFEB signaling attenuates NLRP3-driven inflammatory responses in severe asthma.
Efthymia TheofaniMaria SemitekolouKonstantinos SamitasAnnie MaisIoanna E GalaniVasiliki TriantafylliaJoanna LamaIoannis MorianosAthanasios StavropoulosSe-Jin JeongEvangelos AndreakosBabak RazaniNikoletta RovinaGeorgina XanthouPublished in: Allergy (2022)
Our studies uncover a crucial role for TFEB-mediated reprogramming of monocyte inflammatory responses, raising the prospect that this pathway can be therapeutically harnessed for the management of SA.