Ocular toxicity of intravitreal golimumab in a rabbit model
Ceren Durmaz-EnginSerap Cilaker MiciliOsman YılmazHüsnü Alper BağriyanikBekir Uğur ErgürFatoş ÖnenAli Osman SaatciPublished in: Turkish journal of medical sciences (2020)
Golimumab caused apoptosis in both photoreceptors and bipolar cells of the rabbit retina. Potential retinal toxicity of intravitreal golimumab should be considered if an intravitreal administration is planned.
Keyphrases
- diabetic retinopathy
- cell cycle arrest
- vascular endothelial growth factor
- oxidative stress
- ankylosing spondylitis
- induced apoptosis
- optical coherence tomography
- age related macular degeneration
- ulcerative colitis
- cell death
- optic nerve
- endoplasmic reticulum stress
- pi k akt
- bipolar disorder
- rheumatoid arthritis
- signaling pathway
- disease activity
- oxide nanoparticles
- risk assessment
- human health
- systemic lupus erythematosus