This cat has only eight lives.
Roy C ZiegelsteinBrett D ThombsPublished in: European journal of clinical investigation (2020)
In Shakespeare's Romeo and Juliet, Tybalt asks Mercutio, "What wouldst thou have with me?" With an allusion to the ancient proverb, Mercutio replies, "Good King of Cats, nothing but one of your nine lives." (1) The Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial was a multicenter, international, randomized, double-blind, placebo-controlled trial of spironolactone vs. placebo among 3,445 individuals with symptomatic heart failure with preserved left ventricular ejection fraction (2).
Keyphrases
- double blind
- heart failure
- ejection fraction
- phase iii
- placebo controlled
- left ventricular
- aortic stenosis
- clinical trial
- phase ii
- study protocol
- cardiac resynchronization therapy
- acute myocardial infarction
- open label
- acute heart failure
- angiotensin ii
- aortic valve
- transcatheter aortic valve replacement
- mitral valve
- smoking cessation
- replacement therapy