H X V 2 O 5 Nanocatalysts Combined with Ultrasound for Triple Amplification of Oxidative Stress to Enhance Cancer Catalytic Therapy.
Linqian HouFei GongZhihui HanYuanjie WangYuqi YangShuning ChengNailin YangZhuang LiuLiang ChengPublished in: Angewandte Chemie (International ed. in English) (2022)
Multiple amplification of tumor oxidative stress has been demonstrated as efficient strategy to enhance the reactive oxygen species (ROS)-mediated cancer therapy. Herein, vanadium-based nanocatalysts, hydrogen vanadium bronzes (H X V 2 O 5 , for short HVO), were constructed and employed as novel biocatalysts for amplifying tumor oxidative stress and enhancing cancer catalytic therapy. Such HVO nanocatalysts harboring multivalent V element possessed multi-functional catalytic activity in decomposing H 2 O 2 into ⋅OH and depleting endogenous glutathione (GSH) to dually amplify tumor oxidative stress. Meanwhile, HVO nanocatalysts could also be activated by ultrasound to further triply amplify oxidative stress. The massive intracellular ROS caused mitochondrial dysfunction, DNA damage, cell cycle arrest, and cell proliferation inhibition, further realizing cancer cell death and tumor growth inhibition. Collectively, HVO nanocatalysts highlight the remarkable value of ROS-mediated cancer therapies.
Keyphrases
- oxidative stress
- dna damage
- cell death
- papillary thyroid
- reactive oxygen species
- cell cycle arrest
- squamous cell
- cell proliferation
- ischemia reperfusion injury
- magnetic resonance imaging
- diabetic rats
- dna repair
- induced apoptosis
- lymph node metastasis
- cancer therapy
- stem cells
- squamous cell carcinoma
- mesenchymal stem cells
- bone marrow
- computed tomography
- signaling pathway
- heat shock
- cell therapy
- heat stress