Prognostic Implications of Small Cell Lung Cancer Transcriptional Subtyping for CNS Metastases.
Kathryn R TringaleAnna SkakodubJacklynn EggerJordan EichholzYao YuDaniel GomezAndreas RimnerBob T LiYoshiya YamadaJessica WilcoxNelson S MossBrandon S ImberNatasha RekhtmanMarina K BaineCharles M RudinLuke R G PikePublished in: JCO precision oncology (2024)
To our knowledge, this report is the first to investigate CNS-specific outcomes based on transcription factor subtypes in patients with SCLC. BM-free patients at diagnosis with A+/N- or A-/N+ subtypes had worse outcomes compared with those with transcriptional factor coexpression. Further investigation into the mechanisms and implications of SCLC subtyping on CNS-specific outcomes is warranted to ultimately guide personalized care.
Keyphrases
- transcription factor
- small cell lung cancer
- healthcare
- end stage renal disease
- blood brain barrier
- gene expression
- ejection fraction
- newly diagnosed
- palliative care
- chronic kidney disease
- peritoneal dialysis
- type diabetes
- adipose tissue
- metabolic syndrome
- oxidative stress
- insulin resistance
- chronic pain
- patient reported outcomes
- network analysis