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A high-resolution frequency variable experimental setup for studying ferrofluids used in magnetic hyperthermia.

Ernesto E Mazon ValadezE Villa-MartínezA Hernández-SámanoTeodoro Córdova-FragaJ J Ibarra-SánchezH A CallejaJ A Leyva CruzA BarreraJ C EstradaJ A PazLuis H QuinteroMario Eduardo Cano
Published in: The Review of scientific instruments (2018)
A scanning system for specific absorption rate of ferrofluids with superparamagnetic nanoparticles is presented in this study. The system contains an induction heating device designed and built with a resonant inverter in order to generate magnetic field amplitudes up to 38 mT, over the frequency band 180-525 kHz. Its resonant circuit involves a variable capacitor with 1 nF of capacitance steps to easily select the desired frequency, reaching from 0.3 kHz/nF up to 5 kHz/nF of resolution. The device performance is characterized in order to compare with the theoretical predictions of frequency and amplitude, showing a good agreement with the resonant inverters theory. Additionally, the setup is tested using a synthetic iron oxide with 10 ± 1 nm diameter suspended in liquid glycerol, with concentrations at 1%. Meanwhile, the temperature rise is measured to determine the specific absorption rate and calculate the dissipated power density for each f. This device is a suitable alternative to studying ferrofluids and analyzes the dependence of the power absorption density with the magnetic field intensity and frequency.
Keyphrases
  • high resolution
  • signaling pathway
  • high frequency
  • iron oxide
  • lps induced
  • oxidative stress
  • mass spectrometry
  • high intensity
  • toll like receptor
  • molecularly imprinted
  • functional connectivity