Activation function 1 of progesterone receptor is required for progesterone antagonism of oestrogen action in the uterus.

Shi Hao LeeChew Leng LimWei ShenSamuel Ming Xuan TanAmanda Rui En WooYeannie H Y YapCaitlyn Ang Su SianWilson Wen Bin GohWei-Ping YuLi LiValerie Chun Ling Lin

Published in: BMC biology (2022)

AF1 mediates genomic inhibition of ESR1 action globally whilst it also has tissue-selective effect on PGR target genes.

Keyphrases

estrogen receptor
atrial fibrillation
genome wide
copy number
gene expression
binding protein
genome wide analysis