Mifepristone inhibits IGF-1 signaling pathway in the treatment of uterine leiomyomas.

Qi ShenShuangwei ZouBo ShengMenghuang ZhaoLu-Zhe Sun Xueqiong Zhu

Published in: Drug design, development and therapy (2019)

Our study for the first time demonstrated that IGF-1 signaling via ERK1/2 appears to be an important target of mifepristone in the treatment of uterine leiomyomas, which may provide a new approach to avoid leiomyoma re-growth after cessation of mifepristone.

Keyphrases

signaling pathway
pi k akt
epithelial mesenchymal transition
oxidative stress
growth hormone