Encapsulation of a new quinoxaline derivative in PLGA alters the pattern of its anticancer potency and induces apoptosis.
Entsar A SaadHeba M WalyPublished in: Cancer chemotherapy and pharmacology (2019)
NBPQD-PLGA nano-particles were spherical with diameter around 54 nm. Zeta potential, EE%, and DL% values were - 20.4 mV, 88% and 21.8%, respectively. Nano-particles exhibited higher marked anticancer activities (much lower IC50s) and changed the anticancer potency pattern towards all the studied cell lines compared to free NBPQD with superior potency against colorectal carcinoma (HCT-116, IC50 of 12.2 µg/mL). NBPQD-PLGA acts by induction of cancer cell apoptosis through oxidative stress, DNA damage, and activating a caspase-3 signaling pathway.
Keyphrases
- dna damage
- oxidative stress
- signaling pathway
- drug delivery
- induced apoptosis
- drug release
- bone regeneration
- pi k akt
- papillary thyroid
- dna repair
- cell death
- photodynamic therapy
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- cell proliferation
- squamous cell carcinoma
- squamous cell
- climate change
- human health
- risk assessment
- optical coherence tomography
- water soluble
- light emitting