The rs61742690 (S783N) single nucleotide polymorphism is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching.

Sayed Abdulazeez Shaheen SultanaNoor B AlmandilDana AlmohazeyB Jesvin BencyJesu Francis Borgio

Published in: PloS one (2019)

Complete failure in the protein-protein interactions with functional partners (KLF1 and others) and significant changes (±100% variation) in the interface energy revealed that rs61742690 (S783N) in the zinc-finger domain is a suitable target for disrupting BCL11A-mediated foetal-to-adult globin switching.

Keyphrases

protein protein
small molecule
gestational age
single cell
transcription factor
childhood cancer
young adults
preterm birth