Oncogenic GNAS Uses PKA-Dependent and Independent Mechanisms to Induce Cell Proliferation in Human Pancreatic Ductal and Acinar Organoids.

Ridhdhi Desai Ling Huang Raul S Gonzalez Senthil K Muthuswamy

Published in: Molecular cancer research : MCR (2024)

The study identifies an opportunity to discover a PKA-independent pathway downstream of oncogene GNAS for managing IPMN lesions and their progression to PDAC.

Keyphrases

cell proliferation
endothelial cells
induced pluripotent stem cells
cell cycle
gene expression
dna methylation
pi k akt