Carbon Dots-Based Nanozyme for Drug-Resistant Lung Cancer Therapy by Encapsulated Doxorubicin/siRNA Cocktail.

Hailing YuKexin TangZeyu CaiXi LinYongquan HuangTing YuQianqian ZhangQiang WangLili WuLei YangHong ShanHui Luo

Published in: International journal of nanomedicine (2023)

Taken together, we uncover the potential role of CDs with a combination of siRNA and chemotherapeutics in overcoming chemoresistance of lung cancer by suppressing MRP1 and oxidation of GSH. Our findings imply its potential of antagonizing chemoresistance to enhance therapeutic efficiency of doxorubicin in clinical practices of lung cancer treatment.

Keyphrases

cancer therapy
drug resistant
drug delivery
multidrug resistant
acinetobacter baumannii
healthcare
primary care
quantum dots
hydrogen peroxide
visible light
fluorescent probe
pseudomonas aeruginosa
nitric oxide