Inhibition of Hmbox1 Promotes Cardiomyocyte Survival and Glucose Metabolism Through Gck Activation in Ischemia/Reperfusion Injury.

Yihua BeiYujiao ZhuJingwen ZhouSongwei AiJianhua Yao Mingming Yin Meiyu HuWeitong QiMichail Spanos Lin LiMeng WeiZhenzhen HuangJuan GaoChang LiuPetra H van der KraakGuoping LiZhiyong LeiJoost Petrus Gerardus Sluijter Junjie Xiao

Published in: Circulation (2024)

Our studies unravel a new role for the transcriptional repressor Hmbox1 in exercise-induced physiological cardiac growth. They also highlight the therapeutic potential of targeting Hmbox1 to improve myocardial survival and glucose metabolism after I/R injury.

Keyphrases

ischemia reperfusion injury
left ventricular
free survival
gene expression
oxidative stress
transcription factor
heart failure
heat shock