Examining Immunotherapy Response Using Multiple Radiotracers.

Julian L GoggiSiddesh V HartimathYouyi HwangYun Xuan TanShivashankar KhanapurBoominathan RamasamyLingfan JiangFui Fong YongPeter ChengPeng Wen TanMohamed Ar HusainiTsz Ying YuenBeverly JieuAnn-Marie ChackoAnis LarbiLaurent ReniaCharles JohannesEdward G Robins

Published in: Molecular imaging and biology (2021)

[68Ga]Ga-mNOTA-GZP uptake correlates well with changes in CD8+ T cell populations supporting continued development of granzyme B-based imaging agents for stratification of response to immunotherapy. Early assessment of immunotherapy efficacy with [68Ga]Ga-mNOTA-GZP may allow for the reduction of unnecessary side effects while significantly improving patient management.

Keyphrases

pet ct
high resolution
case report
mass spectrometry
photodynamic therapy
genetic diversity
fluorescence imaging