Gold-iron selenide nanocomposites for amplified tumor oxidative stress-augmented photo-radiotherapy.
Jing-Song LuZhenhu GuoWen-Sheng XieYongjie ChiJunxin ZhangWanling XuXiaoxiao GuoJielin YeYen WeiHong WuJing YuYu-Fen HuangLingyun ZhaoPublished in: Biomaterials science (2021)
The radio-resistance of tumor tissues has been considered a great challenge for cancer radiotherapy (RT).The development of nanoparticle (NP)-based radio-sensitizers can enhance the radio-sensitization of tumor tissues while reducing the side effects to surrounding tissues. However, most of the nano-radiosensitizers show increased radiation deposition with a high-Z element but achieve limited enhancement. Herein, we investigated polyethylene glycol (PEG)-modified gold-iron selenide nanocomposites (Au-FeSe2 NCs) for simultaneously enhancing therapeutic effects in multiple ways. In this study, the high-Z element Au (Z = 79) endows Au-FeSe2 NCs with enhanced X-ray deposition and thus causes more DNA damage. On the other hand, Au-FeSe2 exhibits the ability to produce reactive oxygen species (ROS) by catalyzing endogenous hydrogen peroxide in tumor sites as well as improve the hydrogen peroxide level during ionizing irradiation. Finally, combined with photothermal therapy (PTT), Au-FeSe2 NCs could exhibit a remarkable RT/PTT synergistic effect on tumor treatment.
Keyphrases
- hydrogen peroxide
- dna damage
- oxidative stress
- reduced graphene oxide
- sensitive detection
- reactive oxygen species
- nitric oxide
- radiation induced
- gene expression
- early stage
- visible light
- drug delivery
- radiation therapy
- squamous cell carcinoma
- low dose
- locally advanced
- high resolution
- mass spectrometry
- gold nanoparticles
- combination therapy
- computed tomography
- signaling pathway
- quantum dots
- lymph node metastasis