Role of non-macrophage cell-derived HMGB1 in oxaliplatin-induced peripheral neuropathy and its prevention by the thrombin/thrombomodulin system in rodents: negative impact of anticoagulants.

Maho TsubotaRyotaro FukudaYusuke HayashiTakaya MiyazakiShin UedaRika YamashitaNene KoikeFumiko SekiguchiHidenori WakeShuji WakatsukiYuka UjiieToshiyuki ArakiMasahiro NishiboriAtsufumi Kawabata

Published in: Journal of neuroinflammation (2019)

Our data thus suggests a causative role of HMGB1 derived from non-macrophage cells in oxaliplatin-induced peripheral neuropathy and a thrombin-dependent anti-neuropathic activity of exogenous TMα and, most probably, endogenous TM.

Keyphrases

high glucose
diabetic rats
adipose tissue
induced apoptosis
drug induced
electronic health record
oxidative stress
big data
data analysis
pi k akt