Pharmacogenetics of sodium-glucose co-transporter-2 inhibitors: Validation of a sex-agnostic pharmacodynamic biomarker.

Simeon I TaylorHua-Ren CherngZhinous Shahidzadeh YazdiMay E MontasserHilary B WhitlatchBraxton D MitchellAlan R ShuldinerElizabeth A StreetenAmber L Beitelshees

Published in: Diabetes, obesity & metabolism (2023)

Normalizing data relative to creatinine excretion will facilitate including data from males and females in a single analysis. Furthermore, because our ongoing pharmacogenomic study (NCT02891954) is conducted in healthy individuals, this will facilitate detection of genetic associations with limited confounding by other factors such as HbA1c and renal function.

Keyphrases

electronic health record
big data
clinical decision support
data analysis
uric acid
gene expression
loop mediated isothermal amplification
copy number
metabolic syndrome
label free
artificial intelligence
real time pcr
sensitive detection