β-Hydroxybutyrate Detection with Proton MR Spectroscopy in Children with Drug-Resistant Epilepsy on the Ketogenic Diet.
Jason N NixonRussell P SanetoS D FriedmanPublished in: AJNR. American journal of neuroradiology (2018)
Clinical MR spectroscopy in pediatric patients on the ketogenic diet demonstrated measurable β-hydroxybutyrate, with a strong correlation to β-hydroxybutyrate blood levels. These findings may serve as an effective tool for noninvasive monitoring of ketosis in this population. An inverse correlation between serum β-hydroxybutyrate levels and brain tissue N-acetylaspartate suggests that altered amino acid handling contributes to the antiepileptogenic effect of the ketogenic diet.
Keyphrases
- drug resistant
- weight loss
- physical activity
- multidrug resistant
- amino acid
- acinetobacter baumannii
- high resolution
- single molecule
- magnetic resonance
- young adults
- contrast enhanced
- white matter
- resting state
- solid state
- magnetic resonance imaging
- mass spectrometry
- pseudomonas aeruginosa
- functional connectivity
- real time pcr