Comprehensive clinicopathological and molecular analysis of primary malignant melanoma of the oesophagus.

Sho TsuyamaShinji KohsakaTakuo HayashiYoshiyuki SueharaTakashi HashimotoYoshiaki KajiyamaMasahiko TsurumaruToshihide UenoHiroyuki ManoTakashi YaoTsuyoshi Saito

Published in: Histopathology (2020)

The RAS-mitogen-activated protein kinase pathway is one of the main pathways involved in PMME. The genetic profile of PMME was similar to that of mucosal/acral melanoma, but differed from the SKMM profile. A subset of PMMEs may contain actionable mutations. Immunotherapy seemed to be less effective for most PMMEs in this series.

Keyphrases

genome wide
tyrosine kinase
copy number
ulcerative colitis
gene expression
dna methylation
skin cancer