Repurposing beta-3 adrenergic receptor agonists for Alzheimer's disease: beneficial effects in a mouse model.

Marine TournissacTra-My VuNika VrabicClara HozerCyntia TremblayKoralie MélançonEmmanuel PlanelFabien PifferiFrédéric Calon

Published in: Alzheimer's research & therapy (2021)

Overall, our results indicate that β3AR stimulation reverses memory deficits and shifts downward the insoluble Aβ42/Aβ40 ratio in 16-month-old 3xTg-AD mice. As β3AR agonists are being clinically developed for metabolic disorders, repurposing them in AD could be a valuable therapeutic strategy.

Keyphrases

mouse model
traumatic brain injury
high fat diet induced
cognitive decline
working memory
water soluble
type diabetes
insulin resistance
metabolic syndrome
skeletal muscle