Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells.
Yin XunluMinshan FengZhu LiguoJia-Wen ZhanWei XuYu JieWang ShangquanYin HeLiang LongHan TaoLi XuepengPublished in: BioMed research international (2019)
Low back pain is a major cause of disability worldwide. Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it. The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI. PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD. This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions.
Keyphrases
- signaling pathway
- induced apoptosis
- gene expression
- pi k akt
- bioinformatics analysis
- epithelial mesenchymal transition
- endothelial cells
- multiple sclerosis
- aortic valve
- cell cycle arrest
- human health
- oxidative stress
- genome wide
- transcription factor
- single molecule
- cell proliferation
- induced pluripotent stem cells
- combination therapy
- small molecule
- smoking cessation
- data analysis