Colorectal cancer molecular classification using BRAF, KRAS, microsatellite instability and CIMP status: Prognostic implications and response to chemotherapy.

Oscar MurciaMíriam JuárezMaría Rodríguez-SolerEva Hernández-IllánMar Giner-CalabuigMiren AlustizaCecilia EgoavilAdela CastillejoCristina AlendaVíctor BarberáCarolina Mangas-SanjuanAna YusteLuís BujandaJoan ClofentMontserrat AndreuAntoni CastellsXavier LlorPedro Zapater Rodrigo Jover

Published in: PloS one (2018)

We confirmed the prognostic value of stratifying CRC according to molecular subtypes using MSI, CIMP status, and somatic KRAS and BRAF mutation. Patients with traditional chromosomally unstable tumours obtained the best benefit from adjuvant 5-FU-based chemotherapy.

Keyphrases

wild type
locally advanced
machine learning
early stage
deep learning
metastatic colorectal cancer
single molecule
squamous cell carcinoma
gene expression
radiation therapy
rectal cancer
chemotherapy induced