Increased protease-activated receptor 1 autoantibodies are associated with severe COVID-19.
Florian TranDanielle M M HarrisAlena ScharmacherHanna GraßhoffKristina SternerSusanne SchinkeNadja KädingJens Y HumrichOtávio Cabral-MarquesJoana P BernardesNeha MishraThomas BahmerJeanette FranzenburgBimba Franziska HoyerAndreas GlückMartina A GuggeisAlexander OssysekAndre KüllerDerk FrankChristoph LangeJan RuppJan HeyckendorfKaroline I GaedeHoward AmitalPhilip RosenstielYehuda ShoenfeldGilad HalpertAvi Z RosenbergKai Schulze-ForsterHarald HeideckeGabriela RiemekastenStefan SchreiberPublished in: ERJ open research (2022)
In patients with severe #COVID19, increased levels of autoantibodies against PAR1 were found. These might serve as allosteric agonists of PAR1 on endothelial cells and platelets, and thus might contribute to the pathogenesis of microthrombosis in COVID-19. https://bit.ly/3pqM9Vv.