Sulforaphane triggers Sirtuin 3-mediated ferroptosis in colorectal cancer cells via activating the adenosine 5'-monophosphate (AMP)-activated protein kinase/ mechanistic target of rapamycin signaling pathway.

Bo HuPing CaoJing-Hui WangWei FengYang ZhangHui Yang

Published in: Human & experimental toxicology (2024)

SIRT3 triggered SLC7A11-mediated ferroptosis in HCT-116 cells, reducing cell viability by activating the AMPK/mTOR pathway, and sulforaphane targets it to inhibit colorectal cancer.

Keyphrases

protein kinase
signaling pathway
induced apoptosis
cell cycle arrest
cell death
pi k akt
epithelial mesenchymal transition
oxidative stress
cell proliferation
endoplasmic reticulum stress
skeletal muscle
ischemia reperfusion injury