Involvement of C677T MTHFR variant but not A1298C in methotrexate-induced toxicity in acute lymphoblastic leukemia.

Rim FrikhaMaha Ben JemaaFakher FrikhaInes TurkiMoez ElloumiLeila KeskesHassen KamounTarek Rebai

Published in: Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners (2020)

Our preliminary findings highlight the impact of the C677T variant of MTHFR, but not the A1289C; in HD-MTX chemotherapy-related adverse effects in younger Tunisian ALL.

Keyphrases

acute lymphoblastic leukemia
high glucose
diabetic rats
oxidative stress
allogeneic hematopoietic stem cell transplantation
high dose
drug induced
locally advanced
squamous cell carcinoma
acute myeloid leukemia
radiation therapy
low dose
rectal cancer