Concurrent Joint Contact in Anterior Cruciate Ligament Injury induces cartilage micro-injury and subchondral bone sclerosis, resulting in knee osteoarthritis.
Kei TakahataYu-Yang LinBenjamin OsipovKohei ArakawaSaaya EnomotoBlaine A ChristiansenTakanori KokubunPublished in: bioRxiv : the preprint server for biology (2024)
Both Compression and Non-Compression ACL injury initiated PTOA progression due to joint instability. However, joint contact during ACL rupture also caused initial micro-damage on the cartilage surface and initiated early MMP activity, which could accelerate PTOA progression compared to ACL injury without concurrent joint contact.