Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response.

Ben SiddersPei ZhangKelly GoodwinGreg O'ConnorDeanna L RussellAlexandra BorodovskyJoshua ArmeniaRobert McEwenBolan LinghuJohanna C BendellTodd M BauerManish R PatelGerald S FalchookMelinda MerchantGayle PouliotJ Carl BarrettJonathan R DryRich WoessnerKris Sachsenmeier

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

These data support the adenosine pathway as a mediator of a successful antitumor immune response, demonstrate the prognostic potential of the signature for immunotherapy, and inform patient selection strategies for adenosine pathway modulators currently in development.

Keyphrases

immune response
protein kinase
papillary thyroid
small molecule
case report
electronic health record
squamous cell
big data
toll like receptor
dendritic cells
young adults
machine learning
artificial intelligence
risk assessment
data analysis