AGO2 Protects Against Diabetic Cardiomyopathy by Activating Mitochondrial Gene Translation.

Jiabing ZhanKunying JinRong XieJiahui Fan Yuyan Tang Chen Chen Huaping Li Dao-Wen Wang

Published in: Circulation (2023)

axis links glucotoxicity to cardiac electron transport chain imbalance, providing new mechanistic insights and the basis to develop mitochondria targeting therapies for diabetic cardiomyopathy.

Keyphrases

type diabetes
heart failure
wound healing
oxidative stress
signaling pathway
left ventricular
cell death
copy number
reactive oxygen species
gene expression
drug delivery
dna methylation
atrial fibrillation
transcription factor