Essential oil of the leaves of psychotria asiatica L.: chemical composition, antioxidant, anti-inflammatory, and cytotoxic properties.

This study is focused on investigating the chemical composition and bioactive properties of the essential oil extracted from Psychotria asiatica L., a plant species known for its medicinal properties. Utilising gas chromatography-mass spectrometry (GC-MS) analysis, the essential oil from P. asiatica was found to contain 53 distinct constituents. Major compounds identified include ( E )-citral (20.6%), 10- epi - γ -eudesmol (15.9%), ( Z )-citral (10.5%), geraniol (7.4%), α -cadinol (6.7%), 7- epi - α -eudesmol (4.4%), linalool (3.7%), and α -muurolol (3.4%). The essential oil did not exhibit antioxidant activity, as indicated by an IC 50 value of > 100 µg/mL, whereas the positive control L -Ascorbic acid had an IC 50 of 7.37 ± 0.27 µg/mL in the DPPH model. Assessment of its anti-inflammatory potential revealed an inhibitory effect on NO production, with an IC 50 value of 29.08 ± 1.54 µg/mL in Lipopolysaccharide-induced RAW264.7 macrophage cells. Furthermore, the essential oil demonstrated significant cytotoxicity against the SK-LU-1 cancer cell line, with an IC 50 value of 39.75 ± 1.79 μg/mL according to the sulforhodamine B (SRB) assay.