Plasma endotrophin, reflecting tissue fibrosis, is associated with graft failure and mortality in KTR: results from two prospective cohort studies.
Daan KremerFiras Farisi AlkaffAdrian PostTim J KnobbeMartin TepelOlivier ThaunatStefan P BergerJacob van den BornFederica GenoveseMorten Asser KarsdalDaniel Guldager Kring RasmussenStephan J L Bakkernull nullPublished in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2022)
Plasma endotrophin is strongly associated with graft failure and mortality among KTR. These findings suggest a key role of abnormal extracellular matrix turnover and fibrosis in graft and patient prognosis among KTR, and highlight the need for (interventional) studies targeting the pro-fibrotic state of KTR. The intra-individual stability after transplantation indicates potential use of endotrophin as a biomarker and outcome measure of fibrosis.