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Mastoparan M Suppressed NLRP3 Inflammasome Activation by Inhibiting MAPK/NF-κB and Oxidative Stress in Gouty Arthritis.

Yunbo YanLinqian YuBinyang ChenChang'an CaoHai-Rong ZhaoQiang WangDe XieYuemei XiChenggui ZhangJidong Cheng
Published in: Journal of inflammation research (2023)
Mast-M significantly improves gouty arthritis, and its potential mechanism may be achieved by inhibiting the MAPK/NF-κB pathway and alleviating oxidative stress, thus suppressing the activation of NLRP3 inflammasomes.
Keyphrases
  • signaling pathway
  • nlrp inflammasome
  • oxidative stress
  • induced apoptosis
  • pi k akt
  • rheumatoid arthritis
  • dna damage
  • diabetic rats
  • ischemia reperfusion injury
  • heat shock
  • immune response