Minimal PK/PD model for simultaneous description of the maximal tolerated dose and metronomic treatment outcomes in mouse tumor models.
Ivan N TerterovVyacheslav A ChubenkoNikolay A KnyazevVladimir V KlimenkoAndrei A BogdanovVladimir M MoiseyenkoAlexey A BogdanovPublished in: Cancer chemotherapy and pharmacology (2021)
Our results demonstrate that the proposed model presents a minimal yet efficient tool for modeling outcomes in different treatment regimens in mice. We hope that this model has the potential for use in clinical practice in the development of patient-specific chemotherapy scheduling protocols based on observed treatment response.